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瑞典研究发现司美格鲁肽与双相情感障碍住院风险降低有关
一项针对双相情感障碍患者的瑞典全国性队列研究发现，使用司美格鲁肽药物的患者精神科住院风险降低21%，双相情感障碍复发风险降低17%，而其他GLP-1受体激动剂药物未显示出这种关联。
本文由AI根据下方引用的来源综合生成。
一项覆盖2009年至2024年瑞典双相情感障碍患者的全国性队列研究发现，与未使用该药物的患者相比，使用司美格鲁肽（一种以Ozempic和Wegovy等品牌名而闻名的GLP-1受体激动剂药物）的患者精神科住院风险降低21%，双相情感障碍复发风险降低17%。这项发表在《北欧精神病学报》期刊上的研究基于瑞典国家健康登记数据，纳入14694名双相情感障碍患者，其中5200人曾使用过GLP-1受体激动剂。
值得注意的是，研究人员发现，住院风险的降低仅与司美格鲁肽相关，同类的其他GLP-1受体激动剂药物并未显示出同样的关联，这表明该效应可能并非该类药物的普遍现象。作者表示，这些发现值得进一步研究司美格鲁肽如何影响双相情感障碍患者的精神科结局，同时提醒该研究属于观察性研究，无法确立该药物直接导致风险降低的因果关系。
Key facts
- A Swedish nationwide cohort study included 14,694 people with bipolar disorder, 5,200 of whom used a GLP-1 receptor agonist
- Semaglutide use was linked to a 21% lower risk of psychiatric hospitalization and a 17% lower risk of bipolar relapse
- Other GLP-1 receptor agonist drugs did not show the same association - the effect appeared specific to semaglutide
- The study was published in Acta Psychiatrica Scandinavica and covered 2009 to 2024
Sources
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