Health ·
Utafiti wa Uswidi Waunganisha Semaglutide na Hatari Ndogo ya Kulazwa Hospitalini Katika Ugonjwa wa Bipolar
Utafiti mkubwa wa kikundi wa kitaifa wa Uswidi kuhusu watu wenye ugonjwa wa bipolar uligundua kuwa wale waliotumia dawa ya semaglutide walikuwa na hatari ndogo ya asilimia 21 ya kulazwa hospitalini kwa magonjwa ya akili na hatari ndogo ya asilimia 17 ya kurudia bipolar, uhusiano ambao haukuonekana na dawa nyingine za agonist za kipokezi cha GLP-1.
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Utafiti wa kikundi wa kitaifa wa Uswidi uliohusisha watu wenye ugonjwa wa bipolar kati ya 2009 na 2024 uligundua kuwa wale waliotumia semaglutide, dawa ya agonist ya kipokezi cha GLP-1 inayojulikana zaidi kwa majina ya kibiashara kama Ozempic na Wegovy, walikuwa na hatari ndogo ya asilimia 21 ya kulazwa hospitalini kwa magonjwa ya akili na hatari ndogo ya asilimia 17 ya kurudia bipolar ikilinganishwa na wale ambao hawakutumia dawa hiyo. Utafiti huo, uliochapishwa katika jarida la Acta Psychiatrica Scandinavica, ulitegemea kumbukumbu za kitaifa za afya za Uswidi na ulihusisha watu 14,694 wenye ugonjwa wa bipolar, ambapo 5,200 kati yao walikuwa wametumia agonist ya kipokezi cha GLP-1.
Kwa kustaajabisha, watafiti waligundua kuwa hatari iliyopungua ya kulazwa hospitalini ilikuwa maalum kwa semaglutide na haikuonekana na dawa nyingine za agonist za kipokezi cha GLP-1 katika daraja lile lile, ikionyesha kuwa athari hiyo huenda isiwe jambo rahisi la daraja zima. Waandishi walisema matokeo hayo yanahitaji uchunguzi zaidi kuhusu jinsi semaglutide inavyoweza kuathiri matokeo ya kiakili kwa watu wenye ugonjwa wa bipolar, wakionya kuwa hali ya uchunguzi wa utafiti huo inamaanisha hauwezi kuthibitisha kuwa dawa hiyo husababisha moja kwa moja kupungua kwa hatari.
Key facts
- A Swedish nationwide cohort study included 14,694 people with bipolar disorder, 5,200 of whom used a GLP-1 receptor agonist
- Semaglutide use was linked to a 21% lower risk of psychiatric hospitalization and a 17% lower risk of bipolar relapse
- Other GLP-1 receptor agonist drugs did not show the same association - the effect appeared specific to semaglutide
- The study was published in Acta Psychiatrica Scandinavica and covered 2009 to 2024
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